Bioorganic and Medicinal Chemistry Letters p. 1427 - 1430 (1996)
Update date:2022-08-03
Topics:
Kawanishi, Yasuyuki
Ishihara, Shoichi
Tsushima, Tadahiko
Seno, Kaoru
Miyagoshi, Masanori
Hagishita, Sanji
Ishikawa, Michio
Shima, Noriko
Shimamura, Mayumi
Ishihara, Yasunobu
The chemical modification of the dual histamine H2 and gastrin receptor antagonists described in our preceding paper, particularly the modification of spacers as well as the alteration of their connecting bonds at the gastrin receptor antagonist site (GA) from the amide bond to the carbamate bond, significantly improved not only their dual activity but also the GA versus CCK-A receptor selectivity.
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