Synthesis and pharmacological evaluation of highly potent dual histamine H2 and gastrin receptor antagonists

Article abstract of DOI:10.1016/S0960-894X(96)00249-1

The chemical modification of the dual histamine H₂ and gastrin receptor antagonists described in our preceding paper, particularly the modification of spacers as well as the alteration of their connecting bonds at the gastrin receptor antagonist site (GA) from the amide bond to the carbamate bond, significantly improved not only their dual activity but also the GA versus CCK-A receptor selectivity.