Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class

DOI: 10.1016/S0960-894X(98)00137-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 965 - 970 (1998)

Update date:2022-07-29

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Authors:

Von Sprecher, Andreas

Gerspacher, Marc

Beck, Andreas

Kimmel, Sabine

Wiestner, Hansruedi

Anderson, Gary P.

Niederhauser, Ulrich

Subramanian, Natarajan

Bray, Michael A.

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Article abstract of DOI:10.1016/S0960-894X(98)00137-1

The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4- [3-(7-fluoro-2-quinolinylmethoxy)phenyl-amino]-2,2-diethyl-4-oxo-butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.

Full text of DOI:10.1016/S0960-894X(98)00137-1

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