Effect of Bridge Region Variation on Antifolate and Antitumor Activity of Classical 5-Substituted 2,4-Diaminofuropyrimidines

Article abstract of DOI:10.1021/jm00019a009

Variation of the bridge linking the heterocyclic ring and p-aminobenzoyl-L-glutamate portions of our previously described classical 2,4-diaminofuro<2,3-d>pyrimidines 1 and 2 are reported as inhibitors of dihydrofolate reductase (DHFR) and thymidate syntha