Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5β- configuration

Article abstract of DOI:10.1021/jm00022a021

A series of 7-(2-hydroxyethyl)benz[e]indene analogues of 3α-hydroxy-5β- pregnan-20-one (7), a neuroactive steroid known to be a positive allosteric modulator of GABA(A) receptor function, was prepared. Electrophysiological measurements carried out on cult