Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5β- configuration

DOI: 10.1021/jm00022a021

Source and publish data:

Journal of Medicinal Chemistry p. 4548 - 4556 (1995)

Update date:2022-08-04

Topics:

Authors:

Han Han

Zorumski

Covey Covey

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Article abstract of DOI:10.1021/jm00022a021

A series of 7-(2-hydroxyethyl)benz[e]indene analogues of 3α-hydroxy-5β- pregnan-20-one (7), a neuroactive steroid known to be a positive allosteric modulator of GABA(A) receptor function, was prepared. Electrophysiological measurements carried out on cult

Full text of DOI:10.1021/jm00022a021

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