Resolution, EPC-Syntheses, Absolute Stereochemistry, and Pharmacology of the (S)-(+)- and (R)-(-)-Isomers of the MAO-A Inhibitor Tetrindole Hydrochloride

DOI: 10.1002/ardp.19953280710

Source and publish data:

Archiv der Pharmazie p. 619 - 622 (1995)

Update date:2022-08-04

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Authors:

Boes, Michael

Canesso, Rolf

Kettler, Rolf

Keller, Hans H.

Schoenholzer, Peter

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Article abstract of DOI:10.1002/ardp.19953280710

Resolution of (RS)-tetrindole (3) and enantioselective reductions of the imine 7 yielded (S)-(+)-(4) and (R)-(-)-tetrindole (5).The absolute stereochemistry of 4 was established by X-ray analysis of the corresponding Mosher amide 6.From in vitro as well a

Full text of DOI:10.1002/ardp.19953280710

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