Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

Article abstract of DOI:10.1016/j.saa.2006.04.038

Some platinum (IV) complexes [Pt(L)₂Cl₂] [where, L = 2-aminopyridine-N-thiohydrazide (L¹), (2-aminopyridine-N-thio)-1,3-propanediamine (L²), benzaldehyde-2-aminopyridine-N-thiohydrazone (L³) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L⁴)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and ¹H NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes.