Synthesis of carboxymethylpullulan-peptide-doxorubicin conjugates and their properties

DOI: 10.1248/cpb.43.1931

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1931 - 1936 (1995)

Update date:2022-08-04

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Authors:

Nogusa Nogusa

Yano Yano

Okuno Okuno

Hamana Hamana

Inoue Inoue

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Article abstract of DOI:10.1248/cpb.43.1931

The amino group of doxorubicin (DXR) was found to be bound to the carboxyl group of carboxymethylpullulan (CMPul) either directly or through tetrapeptide spacers, including Gly-Gly-Phe-Gly, Gly-Phe-Gly-Gly and Gly- Gly-Gly-Gly. These conjugates had DXR co

Full text of DOI:10.1248/cpb.43.1931

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