Chelate synthesis of 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine from ethyl acetoacetate and trifluoroacetonitrile

Article abstract of DOI:10.1007/BF00700905

Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF3CN in the presence of Ni(acac)2.Condensation of the diphenylboron chelate of the former with dimethylformamide dimethylacetal followed by refluxi