Synthesis of (S)-4-hydroxy-α-lapachone and biotransformation of some 4-chromanones by Mortierella isabellina ATCC 42613

Article abstract of DOI:10.1139/v95-174

1-Methoxy-2-naphthol was converted by MOM ether formation, lithiation at C-3, reaction with 3,3-dimethylacryloyl chloride, cyclization, and oxidation using cerium ammonium nitrate to 4-keto-α-lapachone (2,2-dimethyl-4-keto-1-oxa-1,2,3,4-tetrahydroanthra-5