Tetrahedron p. 13447 - 13454 (1995)
Update date:2022-07-30
Topics:
Lange, Jos H. M.
Wals, Henri C.
Hoogenband, Adri van den
Kuilen, Aalt van de
Hartog, Jack A. J. den
The previously described route for the synthesis of the histamine H3 antagonist thioperamide 3 has been improved considerably.Furthermore, two straightforward novel synthetic routes towards 3 are described herein.The last synthetic route (Scheme 3) is preferable as it is very suitable for the production of multigram quantities of thioperamide 3.
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(2020)
