Highly Stereoselective Aldol Reaction of Metal Enolates of α-Fluoropropanethioates with Aldehydes Affording erythro-α-Fluoro-α-methyl-β-hydroxy Alkanethioates

Article abstract of DOI:10.1016/0040-4039(95)01774-C

The (Z)-lithium enolate of S-phenyl or S-cyclohexyl α-fluoropropanethioate reacted with aromatic aldehydes with high stereoselectivity but with aliphatic aldehydes with low levels of stereoselection.The corresponding (Z)-titanium enolate, generated from t