Amino acids and peptides. XXVI. Laminin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis

DOI: 10.1248/bpb.18.1714

Source and publish data:

Biological and Pharmaceutical Bulletin p. 1714 - 1717 (1995)

Update date:2022-08-04

Topics:

Authors:

Kawasaki

Namikawa

Mizuta Mizuta

Inoue Inoue

Maeda Maeda

Kakiuchi

Izuno Izuno

Yamamoto

Tsutsumi

Nakagawa

Mayumi Mayumi

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Article abstract of DOI:10.1248/bpb.18.1714

Laminin-related peptide poly(ethylene glycol) hybrid, Tyr-Ile-Gly-Ser- Arg-aminopoly(ethylene glycol) was prepared by the solution method and carboxylated poly(ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly(ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr- Ile-Gly-Ser-Arg-amino(polyethylene glycol) 6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly(ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly(ethylene glycol) hybrid also exhibited an inhibitory effect.

Full text of DOI:10.1248/bpb.18.1714

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