Biological and Pharmaceutical Bulletin p. 1714 - 1717 (1995)
Update date:2022-08-04
Topics:
Kawasaki
Namikawa
Mizuta
Inoue
Maeda
Kakiuchi
Izuno
Yamamoto
Tsutsumi
Nakagawa
Mayumi
Laminin-related peptide poly(ethylene glycol) hybrid, Tyr-Ile-Gly-Ser- Arg-aminopoly(ethylene glycol) was prepared by the solution method and carboxylated poly(ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly(ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr- Ile-Gly-Ser-Arg-amino(polyethylene glycol) 6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly(ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly(ethylene glycol) hybrid also exhibited an inhibitory effect.
View MoreWuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Hangzhou Pharma & Chem Co.,Ltd.
Contact:+86-571-87040515
Address:No,139Qingchun Rd
Wuhan Fortuna Chemical Co.,Ltd
website:http://www.fortunachem.com
Contact:86-27-59207850
Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
ShiJiaZhuang Dowell Chemical Co.,Ltd.
website:http://www.dowechem.com
Contact:+86-13463963265
Address:Xiyangling village, high tech Zone, Shijiazhuang，Hebei, China
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Doi:10.1246/bcsj.50.1532
(1977)Doi:10.1016/0584-8539(95)01452-7
(1995)Doi:10.1021/jm980111x
(1998)Doi:10.1016/0957-4166(95)00429-7
(1996)Doi:10.1016/j.bmcl.2015.05.020
(2015)Doi:10.1021/om950586b
(1996)
