Biological and Pharmaceutical Bulletin p. 1714 - 1717 (1995)
Update date:2022-08-04
Topics:
Kawasaki
Namikawa
Mizuta
Inoue
Maeda
Kakiuchi
Izuno
Yamamoto
Tsutsumi
Nakagawa
Mayumi
Laminin-related peptide poly(ethylene glycol) hybrid, Tyr-Ile-Gly-Ser- Arg-aminopoly(ethylene glycol) was prepared by the solution method and carboxylated poly(ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly(ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr- Ile-Gly-Ser-Arg-amino(polyethylene glycol) 6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly(ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly(ethylene glycol) hybrid also exhibited an inhibitory effect.
View Morezhangjiagang bonded areas banggao co;ltd
website:http://www.shunchangchem.com
Contact:0086-13921972933
Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
shandong lukang animal & plant drug trading co.,ltd.
Contact:15853765968
Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Cerametek Materials（ShenZhen）Co., Ltd.
Contact:+86-755-2324.2554
Address:A3-#9, YongChuan Street, Suite 501
website:http://www.NEM.COM.CN
Contact:+86-393-4411771
Address:The west section of shengli Road,Puyang,Henan Province,China
Xi'an Unique Electronic and Chemical Co., Ltd.
Contact:+86-029-88238008
Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA
Doi:10.1246/bcsj.50.1532
(1977)Doi:10.1016/0584-8539(95)01452-7
(1995)Doi:10.1021/jm980111x
(1998)Doi:10.1016/0957-4166(95)00429-7
(1996)Doi:10.1016/j.bmcl.2015.05.020
(2015)Doi:10.1021/om950586b
(1996)
