Biological and Pharmaceutical Bulletin p. 1714 - 1717 (1995)
Update date:2022-08-04
Topics:
Kawasaki
Namikawa
Mizuta
Inoue
Maeda
Kakiuchi
Izuno
Yamamoto
Tsutsumi
Nakagawa
Mayumi
Laminin-related peptide poly(ethylene glycol) hybrid, Tyr-Ile-Gly-Ser- Arg-aminopoly(ethylene glycol) was prepared by the solution method and carboxylated poly(ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly(ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr- Ile-Gly-Ser-Arg-amino(polyethylene glycol) 6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly(ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly(ethylene glycol) hybrid also exhibited an inhibitory effect.
View MoreShanghai Forever Synthesis Co.,Ltd.
Contact:021-61124658
Address:Zhoukang Road,Pudong New District,Shanghai,China
Shanghai Yudiao Chemistry Technology Co.,Ltd
Contact:0086-18964703211
Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
Penglai Qianwei Chemical Co., Ltd.
Contact:86-535-3357802
Address:Shahelu (north), Penglai, Shandong, China
Jiangsu Allyrise Pharmaceutical Co., Ltd.(expird)
Contact:+86-523-86818997
Address:Taizhou,Jiangsu Province,CHINA
Yantai Derun Liquid Crystal Materials Co. Ltd.
website:http://www.ytderun.com
Contact:86-535-6300169
Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI
Doi:10.1246/bcsj.50.1532
(1977)Doi:10.1016/0584-8539(95)01452-7
(1995)Doi:10.1021/jm980111x
(1998)Doi:10.1016/0957-4166(95)00429-7
(1996)Doi:10.1016/j.bmcl.2015.05.020
(2015)Doi:10.1021/om950586b
(1996)
