Chemistry of novel compounds possessing multifunctional carbon atoms. X. Synthetic studies of efficient and practical chiral derivatizing agents based on the α-cyano-α-fluorophenylacetic acid structure

DOI: 10.1248/cpb.43.1668

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1668 - 1673 (1995)

Update date:2022-09-26

Topics:

Authors:

Takeuchi

Iwashita

Yamada Yamada

Gotaishi

Kurose Kurose

Koizumi Koizumi

Kabuto Kabuto

Kometani

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Article abstract of DOI:10.1248/cpb.43.1668

In order to develop efficient chiral derivatizing agents (CDAs) which can be obtained readily in optically active form, synthetic studies of α-cyano- α-fluorophenylacetic acid (CFPA) analogs, 3a-e and CFNA (14a), were made. Carboxylation of 6a-e obtained

Full text of DOI:10.1248/cpb.43.1668

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