Synthesis of the Antitumor Antibiotic LL-C10037α

DOI: 10.1021/jo00092a004

Source and publish data:

Journal of Organic Chemistry p. 3518 - 3519 (1994)

Update date:2022-09-26

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Authors:

Wipf, Peter

Kim, Yuntae

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Article abstract of DOI:10.1021/jo00092a004

(+/-)-LL-C10037α and its C(4)-epimer were prepared in nine steps from 2,5-dimethoxyaniline.The concise synthetic route represents the first synthesis of this highly functionalized antitumor antibiotic and is useful for the preparation of analogs of the putative pharmacophore of the Ras farnesyltransferase inhibitor manumycin

Full text of DOI:10.1021/jo00092a004

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Product name:2,5-dimethoxyphenylcarbamic acid allyl ester

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