Synthesis of novel 5-fluorouracil derivatives with 1,4-oxaheteroepane moieties

DOI: 10.1016/S0040-4020(98)00815-1

Source and publish data:

Tetrahedron p. 13295 - 13312 (1998)

Update date:2022-08-05

Topics: Purification and characterization Further Optimization Scale-up and Production

Authors:

Gomez, Jose A.

Trujillo, Maria A.

Campos, Joaquin

Gallo, Miguel A.

Espinosa, Antonio

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Article abstract of DOI:10.1016/S0040-4020(98)00815-1

A series of new ring-expanded isosteres (1,4-oxaheteroepanes) of Ftorafur [1-(2-tetrahydrofuranyl)-5-fluorouracil] has been synthesized. The branching of C-3 of the seven-membered cycloacetal and the electronegativity of the Y group on the 3-YCH_{2
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Full text of DOI:10.1016/S0040-4020(98)00815-1

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