Double stereodifferentiation in the Lewis acid promoted crotylation of (S)-2-alkoxypropanal with chiral β-alkyl (E)-crotylsilanes

Article abstract of DOI:10.1016/0040-4039(95)01895-O

The sense and level of 1,2-asymmetric induction have been evaluated in the Lewis acid promoted addition of (E)-crotylsilanes (S)-1 and (R)-2 to (S)-2-alkoxypropanal 3 and 7. These aldehydes are substituted at the α-position with benzyloxy (OBn) to reinfor