Tetrahedron Letters p. 9193 - 9196 (1995)
Update date:2022-08-05
Topics:
Frische, Klaus
Greenwald, Moshe
Ashkenasi, Eli
Lemcoff, N. Gabriel
Abramson, Sarah
Golender, Larisa
Fuchs, Benzion
New and important key podands bearing the cis-1,3,5,7-tetraoxadecalin (TOD) core are reported, viz., 2,6-di(hydroxymethyl)- (2) and 2,6-di(aminomethyl)-cis-l,3,5,7-TOD (6), which lead to the first diazacrown-TOD compounds (9a) and (9b) and a corresponding cryptand (11) in the series. 9a&b exhibit very good alkali and earth-alkali ion inclusion ability with selectivity for K+ and Ba+2. Molecular dynamics (Insight/Discover/AMBER) on the crowns and cryptand were performed, including reparametrized MM3-GE calculations. A convincing case for the TOD based hosts was thus established.
View MoreNantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
BrightGene Bio-Medical Technology Co., Ltd.
website:https://en.bright-gene.com/
Contact:+86-512-62551801
Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
Contact:021
Address:Pudong
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.
Contact:86-022-89880739
Address:10B, Pan China International Center, No. 931 YingKou Road, TangGu, Tianjin, China, 300451
JiangXi Keyuan Biopharma Co., LTD.
Contact:+86-563-6833666
Address:Guangde Fine Chemical Zone, Anhui Province, China
Doi:10.1007/s11172-006-0371-3
(2006)Doi:10.1016/0040-4039(95)02285-6
(1996)Doi:10.1016/0040-4039(94)85218-9
(1994)Doi:10.3987/com-98-8362
(1999)Doi:10.1007/s10847-012-0276-8
(2014)Doi:10.1016/S0960-894X(98)00009-2
(1998)