Bioorganic and Medicinal Chemistry Letters p. 319 - 322 (1998)
Update date:2022-08-05
Topics:
Vaccaro, Wayne D.
Sher, Rosy
Davis Jr., Harry R.
Metabolism initiated SAR studies led to the discovery of a new class of potent 2-azetidinone cholesterol absorption inhibitors. These studies found that a heteroatom at the para position of the C-4 phenyl ring is not a requirement for cholesterol absorption inhibition as was suggested by earlier findings. Substitution of Ph-linker-COOR for PhOMe at the C-4 position enhanced absorption inhibition.
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