Synthesis and protein kinase C inhibitory activities of indane analogs of balanol

DOI: 10.1016/0960-894X(96)00151-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 973 - 978 (1996)

Update date:2022-08-05

Topics:

Authors:

Hu, Hong

Hollinshead, Sean P.

Hall, Steven E.

Kalter, Kiyomi

Ballas, Lawrence M.

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Article abstract of DOI:10.1016/0960-894X(96)00151-5

Regio- and stereoisomeric indane analogs (4-6) of balanol (-)-1, a potent protein kinase C (PKC) inhibitor, were synthesized in which the perhydroazepine of balanol was replaced by an indane nucleus. Analog (-)-4 and its racemic regioisomer 6 were found to have highly potent PKC inhibitory activities. In addition, compound (-)-4 displayed excellent kinase selectivity for PKC over PKA.

Full text of DOI:10.1016/0960-894X(96)00151-5

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