Bioorganic and Medicinal Chemistry Letters p. 973 - 978 (1996)
Update date:2022-08-05
Topics:
Hu, Hong
Hollinshead, Sean P.
Hall, Steven E.
Kalter, Kiyomi
Ballas, Lawrence M.
Regio- and stereoisomeric indane analogs (4-6) of balanol (-)-1, a potent protein kinase C (PKC) inhibitor, were synthesized in which the perhydroazepine of balanol was replaced by an indane nucleus. Analog (-)-4 and its racemic regioisomer 6 were found to have highly potent PKC inhibitory activities. In addition, compound (-)-4 displayed excellent kinase selectivity for PKC over PKA.
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Doi:10.1021/ja01292a015
(1936)Doi:10.1016/0957-4166(95)00433-5
(1996)Doi:10.1055/s-1996-4171
(1996)Doi:10.1246/bcsj.69.431
(1996)Doi:10.1080/07328319608002373
(1996)Doi:10.1021/acs.orglett.0c01763
(2020)
