Synthesis and protein kinase C inhibitory activities of indane analogs of balanol

DOI: 10.1016/0960-894X(96)00151-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 973 - 978 (1996)

Update date:2022-08-05

Topics:

Authors:

Hu, Hong

Hollinshead, Sean P.

Hall, Steven E.

Kalter, Kiyomi

Ballas, Lawrence M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00151-5

Regio- and stereoisomeric indane analogs (4-6) of balanol (-)-1, a potent protein kinase C (PKC) inhibitor, were synthesized in which the perhydroazepine of balanol was replaced by an indane nucleus. Analog (-)-4 and its racemic regioisomer 6 were found to have highly potent PKC inhibitory activities. In addition, compound (-)-4 displayed excellent kinase selectivity for PKC over PKA.

Full text of DOI:10.1016/0960-894X(96)00151-5

Products guided by the article

Product name:1-(4-benzyloxybenzamido)-2-indanone

Cas No:174600-59-0

R&D Labs maybe for 174600-59-0

Nanjing Chemical Material Corp.(NCMC)

website:http://www.njchemm.com

Contact:0086-25-83172879

Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Shanghai doly chemical Co.,Ltd

Contact:+86-21-34716221

Address:No.328,WuHe Roard,MinHang,ShangHai China
Lonzeal Pharmaceuticals Co., Ltd.

website:http://www.lonzeal.com

Contact:+86-13381011962

Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
Changzhou Anyi Biochem Co., Ltd.(expird)

Contact:+86-519-88836158

Address:no,51 caoda
Taizhou KEDE Chemical.Co.,Ltd.

Contact:86-576-84613060

Address:Jiangkou Chemical Zoon

Relevant to this article

Doi:10.1021/ja01292a015
(1936)
Synthesis of Enantiomerically Pure Threo 1-Alkyl-2-benzyloxy-propylamines

Doi:10.1016/0957-4166(95)00433-5
(1996)
Efficient Synthesis of Conjugated (2E)- or (2Z)-En-4-ynoic Acids and (2E,4E)- or (2Z,4E)-Dienoic Acids via Palladium-Catalysed Cross Coupling

Doi:10.1055/s-1996-4171
(1996)
Stable β-sheet formation and enhanced hydrolytic catalysis of a sequential alternating amphiphilic polypeptide containing catalytic triads in a serine protease

Doi:10.1246/bcsj.69.431
(1996)
Tandem radical cyclization-oxygenation of 6-(2,2-dibromovinyl)-1-(2-deoxy-D-erythro-pent-1-enofuranosyl)-uracil: Synthesis of anomeric spiro nucleosides having arabino and ribo configurations

Doi:10.1080/07328319608002373
(1996)
Palladium-Catalyzed Regioselective Coupling Cyclohexenone into Indoles: Atom-Economic Synthesis of β-Indolyl Cyclohexenones and Derivatization Applications

Doi:10.1021/acs.orglett.0c01763
(2020)

Article Doi