Novel approach to the ansamycin antibiotics macbecin I and herbimycin A. A formal total synthesis of (+)-macbecin I

DOI: 10.1016/0040-4020(95)01107-2

Source and publish data:

Tetrahedron p. 3229 - 3246 (1996)

Update date:2022-07-31

Topics:

Authors:

Martin, Stephen F.

Dodge, Jeffrey A.

Burgess, Laurence E.

Limberakis, Chris

Hartmann, Michael

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Article abstract of DOI:10.1016/0040-4020(95)01107-2

The asymmetric syntheses of 25 and 29, which constitutes the C(3)-C(15) segment of the stereochemically complex ansa chain of (+)-macbecin I (1) and herbimycin A (2), respectively, have been achieved. The approach features the furan-hydropyranone transfor

Full text of DOI:10.1016/0040-4020(95)01107-2

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