Diastereoselective Syn-epoxidation of 2-alkyl-4-enamides to epoxyamides: Synthesis of the Merck HIV-1 protease inhibitor epoxide intermediate

DOI: 10.1016/0040-4039(95)00273-F

Source and publish data:

Tetrahedron Letters p. 2195 - 2198 (1995)

Update date:2022-08-03

Topics:

Authors:

Maligres

Upadhyay

Rossen Rossen

Cianciosi

Purick Purick

Eng Eng

Reamer Reamer

Askin Askin

Volante Volante

Reider Reider

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)00273-F

Reaction of 2-alkyl-4-enamides 2, 9-15 with NIS and aqueous sodium bicarbonate results in the diastereoselective formation of the corresponding iodohydrins 3, 16-22 with essentially no iodolactone by-product. This methodology has been successfully employe

Full text of DOI:10.1016/0040-4039(95)00273-F

Products guided by the article

Product name:N,N-diethyl-2-benzyloxy-4-pentenamide

Cas No:175728-34-4

R&D Labs maybe for 175728-34-4

Jiaxing Anrui Material Technology Co., Ltd.

Contact:86-573-82651652 13305832579

Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
ShangHai Original Economy-Trade Develop Co.,Ltd.,

Contact:86-21-68552131

Address:shanghai
Quhua Zhongxing Refrigeration Technology Co.,Ltd.

Contact:+86-5708886618

Address:318 Bulding 2, No.866 Quhua Rd.,Kecheng District
Shenyang Xinyihan Chemical Technology Co., Ltd.

Contact:+86-18525026267

Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
Skyrun Industrial Co.,Ltd(expird)

website:http://www.chinaskyrun.com

Contact:0086-576-84610586

Address:Chemical Development Zone

Relevant to this article

In situ modification of the Grubbs first generation catalyst: A highly controllable metathesis catalyst bearing tridentate Schiff base ligands

Doi:10.1016/j.molcata.2013.04.010
(2013)
Iodine-induced transannular coupling of 1,6-cyclodecadiyne

Doi:10.1016/0040-4039(96)00093-7
(1996)
A rapid and efficient approach to chiral, nonracemic aza sugars from nonsugars. A formal synthesis of 1,4-dideoxy-1,4-imino-D-lyxitol

Doi:10.1021/jo960129k
(1996)
Probing enzyme stereospecificity. Inhibition of α-chymotrypsin and subtilisin Carlsberg by chiral amine- and aminoalcohol-derivatives

Doi:10.1016/0040-4020(96)00078-6
(1996)
Colloid and nanodimensional catalysts in organic synthesis: III. Alkylation of amines with primary alcohols catalyzed by colloidal nickel and cobalt

Doi:10.1134/S1070363214050065
(2014)
Enantioselective synthesis of the 13-membered macrodiolide bartanol

Doi:10.1039/p19960000637
(1996)

Article Doi