Diastereoselective Syn-epoxidation of 2-alkyl-4-enamides to epoxyamides: Synthesis of the Merck HIV-1 protease inhibitor epoxide intermediate

DOI: 10.1016/0040-4039(95)00273-F

Source and publish data:

Tetrahedron Letters p. 2195 - 2198 (1995)

Update date:2022-08-03

Topics:

Authors:

Maligres

Upadhyay

Rossen Rossen

Cianciosi

Purick Purick

Eng Eng

Reamer Reamer

Askin Askin

Volante Volante

Reider Reider

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Article abstract of DOI:10.1016/0040-4039(95)00273-F

Reaction of 2-alkyl-4-enamides 2, 9-15 with NIS and aqueous sodium bicarbonate results in the diastereoselective formation of the corresponding iodohydrins 3, 16-22 with essentially no iodolactone by-product. This methodology has been successfully employe

Full text of DOI:10.1016/0040-4039(95)00273-F

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Product name:N,N-diethyl-2-benzyloxy-4-pentenamide

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