Bioorganic and Medicinal Chemistry Letters p. 543 - 546 (1996)
Update date:2022-07-30
Topics:
Ohba, Tsuyoshi
Tsuchiya, Naoki
Nishimura, Kuniko
Ikeda, Eitatsu
Wakayama, Jun
Takei, Hisashi
The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepared as novel mechanism-based inactivators of α-chymotrypsin. The esters inactivated α-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward α-chymotrypsin.
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(1968)
