One-pot preparation of isomeric acetyl- and 2,2,2-trifluoroacetyl-azidothiophenes by selective bifunctionalization of dibromothiophenes via halogen-lithio exchange

DOI: 10.1039/P19960000963

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 963 - 964 (1996)

Update date:2022-08-02

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Authors:

Spagnolo, Piero

Zanirato, Paolo

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Article abstract of DOI:10.1039/P19960000963

A series of isomeric acetyl- (1) and 2,2,2-trifluoroacetyl-azidothiophenes (2) are prepared from 2,3-, 3,4- and 2,5-dibromothiophenes via a one-pot procedure entailing stepwise halogen-lithium exchange and successive reaction of the resulting thienyllithium derivatives with N,N-dimethyl-acetamide (or N,N-diethyl-2,2,2-trifluoroacetamide) and tosyl azide.

Full text of DOI:10.1039/P19960000963

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