Stereospecific synthesis of the anaesthetic levobupivacaine

DOI: 10.1016/0040-4039(96)01357-3

Source and publish data:

Tetrahedron Letters p. 6399 - 6402 (1996)

Update date:2022-08-05

Topics:

Authors:

Adger, Brian

Dyer, Ulrich

Hutton, Gordon

Woods, Martin

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Article abstract of DOI:10.1016/0040-4039(96)01357-3

Enantiomerically pure (S)-bupivacaine is synthesized from the chiral pool using cheap and readily available (S)-lysine. The key steps in this efficient synthesis include an oxidative de-amination and stereospecific ring closure to form the pipecolamide core structure.

Full text of DOI:10.1016/0040-4039(96)01357-3

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