Tetrahedron Letters p. 6399 - 6402 (1996)
Update date:2022-08-05
Topics:
Adger, Brian
Dyer, Ulrich
Hutton, Gordon
Woods, Martin
Enantiomerically pure (S)-bupivacaine is synthesized from the chiral pool using cheap and readily available (S)-lysine. The key steps in this efficient synthesis include an oxidative de-amination and stereospecific ring closure to form the pipecolamide core structure.
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Doi:10.1016/1381-1169(95)00301-0
(1996)Doi:10.1007/s10886-008-9432-4
(2008)Doi:10.1039/d0cc00434k
(2020)Doi:10.1016/0040-4039(96)00857-X
(1996)Doi:10.1021/ja01146a053
(1951)Doi:10.1016/0040-4039(96)01576-6
(1996)
