Synthesis of 1-deoxy-1-C-(p-aniline)-β-D-ribofuranose and its incorporation into hammerhead ribozymes

Article abstract of DOI:10.1016/0040-4039(96)01576-6

p-AnilineC-ribofuranoside 11 was prepared in 5 steps from 1-bromo-4-lithiobenzene (1) and D-ribono-1,4 lactone 2. A three step derivatization of 11 yielded 3'-O-phosphoramidite 14 which was incorporated into ribozymes using the solid phase phosphoramidite procedure.