Two-step conversion of 2-substituted furans into γ-oxo-α,β-unsaturated carboxylic acids. Formal synthesis of (+)-patulolide A and (-)-pyrenophorin

Article abstract of DOI:10.1016/0040-4039(96)00857-X

NBS oxidation of 2-substituted furans 9 and 15 followed by further oxidation of the enals with NaClO₂ afforded the acids 11 and 17 in good yields, which are the intermediates of (+)-patulolide A and (-)-pyrenophorin, respectively.