Synthesis of sialyl Lewis X analogues

Article abstract of DOI:10.1080/07328309608005661

Sialyl Lewis X (SLe^x) analogs 2a and 2b were synthesised, where the N-acetyl-D-glucose and the D-galactose units of SLe^x 1 were replaced with an alkyl and a heteroalkyl spacer. Sulphate ester 6i was also synthesised from alcohol 6b and chlorosulphonic acid. A novel promoter, silver mercaptoethanesulphonate, was used to synthesise α-sialosides 2c, 7b and 7c.

Full text of DOI:10.1080/07328309608005661

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Journal of Carbohydrate Chemistry
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Synthesis of Sialyl Lewis X Analogues
Gyula Dekany a , Karen Wright a , Peter Ward b & Istvan Toth a
a The School of Pharmacy , University of London , 29–39 Brunswick
Square, London, WC1N 1AX
b Glaxo Group Research Ltd. , Greenford Road, Greenford, UB6 0RE,
UK
Published online: 22 Aug 2006.
To cite this article: Gyula Dekany , Karen Wright , Peter Ward & Istvan Toth (1996) Synthesis
of Sialyl Lewis X Analogues, Journal of Carbohydrate Chemistry, 15:4, 383-398, DOI:
10.1080/07328309608005661
To link to this article: http://dx.doi.org/10.1080/07328309608005661
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