Synthesis of new 5′-sulfonylamido derivatives of 3′-azido-3′-deoxythymidine (AZT)

Article abstract of DOI:10.1080/07328319608007387

A series of 5′-N-methanesulfonyl derivatives of 3′-azido-5′-(alkylamino)-3′,5′-dideoxythymidine was synthesised. The first step of the synthesis involved the reaction of 1-(2,5-dideoxy-5-O-tosyl-β-D-threo-pentofuranosyl)thymine 1 with an appropriate amine