Journal of Heterocyclic Chemistry p. 873 - 881 (2021)
Update date:2022-08-04
Topics: Yield Catalyst Chromatography C-N Bond Formation Reaction Optimization Spectroscopic Analysis Heterocyclic compound C-S bond formation Solvent-free reaction Mechanochemistry Mechanochemical synthesis Ball milling
Sethiya, Ayushi
Sahiba, Nusrat
Soni, Jay
Agarwal, Shikha
A series of substituted 5-chloro-2-arylbenzo[d]thiazoles were synthesized using 4-chloro-2-aminothiophenol and aromatic aldehydes in the presence of urea nitrate as a catalyst using the mechanochemical grindstone technique. This protocol was effectively carried out under metal-free conditions at room temperature, and the desired products were obtained in high to excellent yields in short reaction time (30–60 s). The structure of all the synthesized derivatives was confirmed by spectral characterization. The designed protocol has several benefits like eco-friendly, solvent-free, high yields, easy workup, and recyclability of catalyst. The catalyst was reusable at least four times without significant loss of activity. The good functional group tolerance with a series of derivatives has been demonstrated.
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