A novel synthesis of (+)-azimic acid

DOI: 10.1248/cpb.44.1282

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1282 - 1284 (1996)

Update date:2022-07-29

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Authors:

Kiguchi, Toshiko

Shirakawa, Mitsuko

Ninomiya, Ichiya

Naito, Takeaki

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Article abstract of DOI:10.1248/cpb.44.1282

A combination of 1,3-dipolar cycloaddition of Z-nitrone (2) to the chiral dipolarophile (3) and subsequent ring transformation of the resulting adducts (4 and 6) to piperidinol (17) has provided a new practical synthesis of 2,3,6-trisubstituted piperidine alkaloid, (+)-azimic acid (1).

Full text of DOI:10.1248/cpb.44.1282

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