Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists

Article abstract of DOI:10.1016/0040-4039(96)00919-7

Enantiomerically pure pyrrolidinones were synthesized as endothelin receptor antagonists. A [2 + 2] cycloaddition of an imine and an enantiomerically pure acid chloride gave two diastereomeric β-lactams which were separated and rearranged to give the enantiomerically pure pyrrolidinones which could be reduced to give the corresponding pyrrolidines.