Synthesis and biological evaluation of 4-alkoxysubstituted trinems. Part II

DOI: 10.1016/0960-894X(96)00358-7

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Bioorganic and Medicinal Chemistry Letters p. 2025 - 2030 (1996)

Update date:2022-08-02

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Authors:

Di Fabio, Romano

Andreotti, Daniele

Biondi, Stefano

Gaviraghi, Giovanni

Rossi, Tino

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Article abstract of DOI:10.1016/0960-894X(96)00358-7

The synthesis and the microbiological evaluation of a novel series of substituted tricyclic β-lactam derivatives (trinems, former named tribactams) is reported. Suitable basic groups were introduced within the key C-4 side chain with the aim of improving the antibacterial activity of this class of new antibiotics to Pseudomonas spp.. Among the different compounds prepared, basic derivatives 2 and 3 showed improved activity with respect to GV104326 1 against these highly resistant strains.

Full text of DOI:10.1016/0960-894X(96)00358-7

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