Synthesis and biological evaluation of 4-alkoxysubstituted trinems. Part II

DOI: 10.1016/0960-894X(96)00358-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2025 - 2030 (1996)

Update date:2022-08-02

Topics:

Authors:

Di Fabio, Romano

Andreotti, Daniele

Biondi, Stefano

Gaviraghi, Giovanni

Rossi, Tino

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00358-7

The synthesis and the microbiological evaluation of a novel series of substituted tricyclic β-lactam derivatives (trinems, former named tribactams) is reported. Suitable basic groups were introduced within the key C-4 side chain with the aim of improving the antibacterial activity of this class of new antibiotics to Pseudomonas spp.. Among the different compounds prepared, basic derivatives 2 and 3 showed improved activity with respect to GV104326 1 against these highly resistant strains.

Full text of DOI:10.1016/0960-894X(96)00358-7

Products guided by the article

Product name:(3S,4R)-4-{(1R,2S,3S)-3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-2-hydroxy-cyclohexyl}-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one

Cas No:181421-53-4

R&D Labs maybe for 181421-53-4

Laizhou City Laiyu Chemical CO.,Ltd

Contact:+86-535-2719337/2719339

Address:Chenggang road zhuyou laizhou City Shangdong China
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)

Contact:+86-21-54159691

Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD

Contact:+86-755-82412922

Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Wuxi Forest Biological Co.,Ltd

Contact:+86-510-81602300

Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
Quhua Zhongxing Refrigeration Technology Co.,Ltd.

Contact:+86-5708886618

Address:318 Bulding 2, No.866 Quhua Rd.,Kecheng District

Relevant to this article

PdCl₂ and NiCl₂-catalyzed hydrogen-halogen exchange for the convenient preparation of bromo- and iodosilanes and germanes

Doi:10.1016/S0022-328X(02)02147-2
(2003)
A ring-transformation/ring-annulation strategy for the synthesis of the DHFR inhibitor, TNP-351: A correction

Doi:10.1021/jo961230s
(1996)
Sodium dithionite initiated addition of CF₂Br₂, CF₃I and (CF₃)₂CFI to allylaromatics. Synthesis and the reactivity of 4-aryl-1,1-difluorodienes and 4-aryl-1,1-bis(trifluoromethyl)dienes

Doi:10.1016/j.jfluchem.2007.04.028
(2007)
Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

Doi:10.1021/acs.jmedchem.9b01457
(2020)
Two types of intramolecular Lewis-base adducts with the [2-(dimethylamino)ethyl]cyclopentadienyl ligand: Synthesis and crystal structures of {η⁵:η¹-C₅H₄[(CH ₂)₂NMe₂]}Ni-I and {η⁵-μ-C₅H₄[(CH₂) ₂NMe₂]}(Me₃P)Ni-InI₂

Doi:10.1021/om960712r
(1996)
Preparation and unequivocal identification of the regioisomers of nitrocatechol monobenzyl ether

Doi:10.1080/00397911.2017.1334919
(2017)

Article Doi