Tetrahedron Letters p. 5325 - 5328 (1996)
Update date:2022-08-02
Topics:
Liu, Weimin
Walker II, John A.
Chen, Jiong J.
Wise, Dean S.
Townsend, Leroy B.
A direct metalation method has been developed for the synthesis of novel pyrazine C-nucleosides. The regiochemistry was controlled by selecting different substituents on the pyrazine ring and excellent stereoselectivity was achieved via a hydride delivery strategy. The scope and limitations of this method were studied. The uniquely designed 4b is a versatile synthon for the preparation of other pyrazine C-nucleosides.
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(1996)
