Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/Sandostatin

Article abstract of DOI:10.1016/0960-894X(96)00289-2

Based on molecular modelling studies of Sandostatin, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin. These compounds displaced 3-[¹²⁵I]-Tyr¹¹-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC₅₀ values between 10 and 15 μM.