Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/Sandostatin

DOI: 10.1016/0960-894X(96)00289-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1667 - 1672 (1996)

Update date:2022-09-26

Topics:

Authors:

Damour, Dominique

Barreau, Michel

Blanchard, Jean-Charles

Burgevin, Marie-Claude

Doble, Adam

Herman, Frederic

Pantel, Guy

James-Surcouf, Evelyne

Vuilhorgne, Marc

Mignani, Serge

Poitout, Lydie

Le Merrer, Yves

Depezay, Jean-Claude

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Article abstract of DOI:10.1016/0960-894X(96)00289-2

Based on molecular modelling studies of Sandostatin, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin. These compounds displaced 3-[¹²⁵I]-Tyr¹¹-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC₅₀ values between 10 and 15 μM.

Full text of DOI:10.1016/0960-894X(96)00289-2

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