Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/Sandostatin

DOI: 10.1016/0960-894X(96)00289-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1667 - 1672 (1996)

Update date:2022-09-26

Topics:

Authors:

Damour, Dominique

Barreau, Michel

Blanchard, Jean-Charles

Burgevin, Marie-Claude

Doble, Adam

Herman, Frederic

Pantel, Guy

James-Surcouf, Evelyne

Vuilhorgne, Marc

Mignani, Serge

Poitout, Lydie

Le Merrer, Yves

Depezay, Jean-Claude

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00289-2

Based on molecular modelling studies of Sandostatin, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin. These compounds displaced 3-[¹²⁵I]-Tyr¹¹-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC₅₀ values between 10 and 15 μM.

Full text of DOI:10.1016/0960-894X(96)00289-2

Products guided by the article

Product name:(3S,4R,5R,6S)-4,5-Bis-benzyloxy-3,6-dihydroxy-azepane-1-carboxylic acid tert-butyl ester

Cas No:182066-46-2

R&D Labs maybe for 182066-46-2

QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Qingzhou Baibang import and export co.,Ltd

Contact:+86-536-3265899

Address:No.338, Tuoshan Road
Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone
Shanghai Potomer International Trade CO., LTD

Contact:+86-21-61397128

Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Shanghai Mio Chemical Co., Ltd

Contact:0086 21- 64401188-622

Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China

Relevant to this article

Asymmetric “Acetylenic” [3+2] Cycloaddition of Nitrones Catalyzed by Cationic Chiral Pd^II Lewis Acid

Doi:10.1002/asia.201801016
(2018)
Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitos of Candida albicans myristoylCoA:protein N- myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity

Doi:10.1021/jm970094w
(1997)
Doi:10.1021/jo01065a044
(1961)
A practical synthesis of (1S, 2R)-1-amino-2-indanol, a key component of HIV protease inhibitor, indinavir

Doi:10.1055/s-1998-3126
(1998)
EXTRAORDINARY PHOTOREARRANGEMENT OF SILYFURANS AND SUBSEQUENT THERMAL REARRANGEMENTS.

Doi:10.1021/ja00358a025
(1983)
Facile synthetic entry into the 1,3-dihydro-3-methyl-3-phenyl-1,2-benziodoxole family of λ³-iodanes

Doi:10.1016/0040-4039(96)01436-0
(1996)

Article Doi