Thermal cleavage of oxazolidine-4,5-diones to imines: A short synthesis of 3,4-dihydro-3,3-dimethyl-7-trifluoromethylisoquinoline-2-oxide

Article abstract of DOI:10.1080/00397919608003751

A series of oxazolidine-4,5-diones 2 was thermally cleaved to cyclic imines 3 in excellent yield. This reaction was utilized in an efficient synthesis of a 3,4-dihydroisoquinoline-based nitrone 1b.

Full text of DOI:10.1080/00397919608003751

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Synthetic Communications: An
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Organic Chemistry
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Thermal Cleavage of
Oxazolidine-4,5-diones to
Imines: A Short Synthesis of
3,4-Dihydro-3,3-dimethyl-7-
trifluoromethylisoquinoline-2-
oxide
Ronald C. Bernotas a , Ginette Adams a & Thaddeus
R. Nieduzak a
a Hoechst Marion Roussel , 2110 E. Galbraith Road,
Cincinnati, OH, 45215
Published online: 21 Aug 2006.
To cite this article: Ronald C. Bernotas , Ginette Adams & Thaddeus R. Nieduzak
(1996) Thermal Cleavage of Oxazolidine-4,5-diones to Imines: A Short Synthesis
of 3,4-Dihydro-3,3-dimethyl-7-trifluoromethylisoquinoline-2-oxide, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 26:18, 3471-3477, DOI: 10.1080/00397919608003751
To link to this article: http://dx.doi.org/10.1080/00397919608003751
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