The synthesis of novel macrocyclic inhibitors of human renin

Article abstract of DOI:10.1016/S0040-4039(00)74351-6

As part of an effort to develop human renin inhibitors with improved biovailability, macrocyclic renin inhibitors 1 and 2 were prepared. These macrocycles were constructed from an analog of "ACHPA" ((3S, 4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)