The synthesis of novel macrocyclic inhibitors of human renin

DOI: 10.1016/S0040-4039(00)74351-6

Source and publish data:

Tetrahedron Letters p. 2453 - 2456 (1991)

Update date:2022-07-29

Topics:

Authors:

Rivero Rivero

Greenlee

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Article abstract of DOI:10.1016/S0040-4039(00)74351-6

As part of an effort to develop human renin inhibitors with improved biovailability, macrocyclic renin inhibitors 1 and 2 were prepared. These macrocycles were constructed from an analog of "ACHPA" ((3S, 4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid) View More

Full text of DOI:10.1016/S0040-4039(00)74351-6

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