Chemoenzymic synthesis of P(α)-methyl deoxynucleoside triphosphates

Article abstract of DOI:10.1080/07328319608002447

5'-O-(methylphosphonyl)-N-(phenylacetyl)-2'-deoxycytidine, deoxyadenosine and deoxyguanosine were pyrophosphorylated and the resulting N-protected P(α)-methyl nucleoside triphosphates were deblocked by treatment with penicillin amidase at pH 7.8, 25°C to give P(α)-methyl nucleoside triphosphates.

Full text of DOI:10.1080/07328319608002447

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Nucleosides and Nucleotides
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Chemoenzymic Synthesis of Pα-Methyl
Deoxynucleoside Triphosphates
Magda A. Dineva a & Dimiter D. Petkov a
a Laboratory of BioCatalysis , Institute of Organic Chemistry,
Bulgarian Academy of Sciences , 1113, Sofia, Bulgaria
Published online: 20 Aug 2006.
To cite this article: Magda A. Dineva & Dimiter D. Petkov (1996) Chemoenzymic Synthesis of
Pα-Methyl Deoxynucleoside Triphosphates, Nucleosides and Nucleotides, 15:9, 1459-1467, DOI:
10.1080/07328319608002447
To link to this article: http://dx.doi.org/10.1080/07328319608002447
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