Stereocontrolled sequential functionalization in acyclic systems by exploiting internal 1,2-asymmetric induction - Generation of symmetry-related polyamino alcohol motifs

Article abstract of DOI:10.1016/0040-4039(96)01754-6

Treatment of acyclic γ-ureido α,β-unsaturated esters with lithium dialkyl or diaryl cuprates leads to the corresponding β,γ-substituted esters with high syn-stereoselectivity. The potassium enolates of these compounds react with trisyl azide or the Davis