A synthesis of functionalized indoline 2,2-biscarboxylates

Article abstract of DOI:10.1016/0040-4039(96)01573-0

A synthetic approach to a structurally novel series of indoline 2,2-biscarboxylates is described that employs a tandem bis-alkylation strategy to cyclize the indoline heteroring from the bromide 7 and diethyl bromomalonate. The indolines thus prepared may be N-deprotected and further functionalized on the indoline nitrogen.