Synthesis of Macarpine and its Cytotoxicity: Toward a Synthetic Route for 12-Alkoxybenzophenanthridine Alkaloids through Aromatic Nitrosation under Basic Condition

Article abstract of DOI:10.1016/0040-4020(95)00460-P

Macarpine (1), a 2,3,7,8,10,12-hexaoxygenated benzophenanthridine alkaloid (O6 base), was effectively synthesized from sesamol methyl ether (7) through the newly developed aromatic nitrosation under basic condition.The tests for the cytotoxicity of 1 a