Synthesis of N-α-aminoacyl derivatives of melphalan for potential use in drug targeting

Article abstract of DOI:10.1016/0040-4039(96)01665-6

N-L- and D-alanyl derivatives (9a, 9b) of melphalan (1) have been synthesized in eight steps (9a, 22%; 9b, 18% overall yield) from p-nitro-L-phenylalanine.