Bioorganic and Medicinal Chemistry Letters p. 2635 - 2640 (1998)
Update date:2022-08-03
Topics:
Montana, John G.
Buckley, George M.
Cooper, Nicola
Dyke, Hazel J.
Gowers, Lewis
Gregory, Joanna P.
Hellewell, Paul G.
Kendall, Hannah J.
Lowe, Christopher
Maxey, Robert
Miotla, Jadwiga
Naylor, Robert J.
Runcie, Karen A.
Tuladhar, Bishwa
Warneck, Julie B. H.
A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding site. In vivo studies demonstrate a reduced propensity to display the emetic side effects which are commonly observed with PDE4 inhibitors.
View MoreContact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
SICHUAN TONGSHENG AMINOACID CO.LTD
website:http://www.aminoacid.cc
Contact:86-838-2274206/2850606
Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Zhangjiagang Jianing Import & Export Co.,Ltd.
Contact:086-512-55379012 13913607595
Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
Contact:86-021-52418058
Address:8/F, Building 6, Guiping Road No.333, Shanghai, 200233, China
Chongqing Changfeng Chemical Co., Ltd.
website:http://www.changfengchem.com
Contact:+86-23-67896333
Address:30th Floor, Longhu Ziduxingzuo Building A, 1st Branch,YuSong Rd., Yubei District, Chongqing, China
Doi:10.1021/jm301217c
(2012)Doi:10.1021/ic300872m
(2012)Doi:10.1021/jm301212u
(2012)Doi:10.1007/BF00901092
(1967)Doi:10.1039/c2ob26103k
(2012)Doi:10.1016/j.bmcl.2012.08.089
(2012)
