Bioorganic and Medicinal Chemistry Letters p. 2635 - 2640 (1998)
Update date:2022-08-03
Topics:
Montana, John G.
Buckley, George M.
Cooper, Nicola
Dyke, Hazel J.
Gowers, Lewis
Gregory, Joanna P.
Hellewell, Paul G.
Kendall, Hannah J.
Lowe, Christopher
Maxey, Robert
Miotla, Jadwiga
Naylor, Robert J.
Runcie, Karen A.
Tuladhar, Bishwa
Warneck, Julie B. H.
A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding site. In vivo studies demonstrate a reduced propensity to display the emetic side effects which are commonly observed with PDE4 inhibitors.
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