Synthesis of derivatives of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnins

DOI: 10.1039/P19960001427

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 1427 - 1433 (1996)

Update date:2022-08-03

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Authors:

Gonzalez, Isabel

Jou, Gemma

Caba, Josep Maria

Albericio, Fernando

Lloyd-Williams, Paul

Giralt, Ernest

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Article abstract of DOI:10.1039/P19960001427

The syntheses of the two protected derivatives 7 and 16 of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnin family of antineoplastic macrocyclic depsipeptides are described. The preparation of 7 was carried out by modificat

Full text of DOI:10.1039/P19960001427

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