A unified total synthesis of the immunomodulators (-)-rapamycin and (-)-27-demethoxyrapamycin: Construction of the C(21-42) perimeters

DOI: 10.1021/ja963066w

Source and publish data:

Journal of the American Chemical Society p. 947 - 961 (1997)

Update date:2022-08-04

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Authors:

Smith III, Amos B.

Condon, Stephen M.

McCauley, John A.

Leazer Jr., Johnnie L.

Leahy, James W.

Maleczka Jr., Robert E.

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Article abstract of DOI:10.1021/ja963066w

A total synthesis of the potent, naturally occurring immunomodulators (-)-rapamycin (1) and (-)-27-demethoxyrapamycin (2) has been achieved via a unified, highly convergent synthetic strategy. Both targets were elaborated from common building blocks A-E,

Full text of DOI:10.1021/ja963066w

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