Bioorganic and Medicinal Chemistry Letters p. 89 - 94 (1997)
Update date:2022-08-03
Topics:
Hlasta, Dennis J.
Bode, Donald C.
Court, John J.
Desai, Ranjit C.
Pagani, Edward D.
Silver, Paul J.
Hybrid structural analogs 1 of the PDE V and PDE III inhibitors, zaprinast, milrinone, and CI-930 were prepared to identify dual PDE inhibitors. The SAR study led unexpectedly to the identification of WIN 61691 (8d), a potent inhibitor of PDE I (IC50 = 85 nM). A potent and selective inhibitor of PDE I would be a useful tool to elucidate the physiologic function of PDE I and other PDE isozymes in biological systems.
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