Bioorganic and Medicinal Chemistry Letters p. 89 - 94 (1997)
Update date:2022-08-03
Topics:
Hlasta, Dennis J.
Bode, Donald C.
Court, John J.
Desai, Ranjit C.
Pagani, Edward D.
Silver, Paul J.
Hybrid structural analogs 1 of the PDE V and PDE III inhibitors, zaprinast, milrinone, and CI-930 were prepared to identify dual PDE inhibitors. The SAR study led unexpectedly to the identification of WIN 61691 (8d), a potent inhibitor of PDE I (IC50 = 85 nM). A potent and selective inhibitor of PDE I would be a useful tool to elucidate the physiologic function of PDE I and other PDE isozymes in biological systems.
View Morewebsite:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Purestar Chem Enterprise Co.,Ltd
website:http://www.purestarchem.com
Contact:05722157374
Address:no235.huanchengdong Rd
Contact:+86-134-5286-9121
Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,
ShangHai Original Economy-Trade Develop Co.,Ltd.,
Contact:86-21-68552131
Address:shanghai
Luoyang Aoda chemical Co.,Ltd.
Contact:+86-379-67518785 67516588
Address:MiaoWan industry district,YanShi City,Henan,China
Doi:10.1016/j.ejmech.2015.01.064
(2015)Doi:10.1016/0040-4039(96)00777-0
(1996)Doi:10.1021/om4010862
(2014)Doi:10.1021/jo01267a052
(1968)Doi:10.1039/c39930001226
(1993)Doi:10.1016/S0020-1693(00)83155-2
(1989)
