Bioorganic and Medicinal Chemistry Letters p. 89 - 94 (1997)
Update date:2022-08-03
Topics:
Hlasta, Dennis J.
Bode, Donald C.
Court, John J.
Desai, Ranjit C.
Pagani, Edward D.
Silver, Paul J.
Hybrid structural analogs 1 of the PDE V and PDE III inhibitors, zaprinast, milrinone, and CI-930 were prepared to identify dual PDE inhibitors. The SAR study led unexpectedly to the identification of WIN 61691 (8d), a potent inhibitor of PDE I (IC50 = 85 nM). A potent and selective inhibitor of PDE I would be a useful tool to elucidate the physiologic function of PDE I and other PDE isozymes in biological systems.
View MoreSpringchem New Material Technology Co.,Limited
website:http://www.spring-chem.com
Contact:86-21-62885108
Address:602B, Building 1, No. 641, Tianshan Road
Jiangsu Cale New Material Co.ltd
Contact:+86-515-88334667/88203550
Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
KINHENG CHEMICAL(SHANGHAI)CO., LTD.
Contact:+8621-60490170
Address:Room401, No.28,Lane 189, Yangshupu Rd. Shanghai, China.
JIANGXI XINXIN CHEMICAL CO., LTD.
Contact:86-15957176628
Address:INDUSTRY ROAD 1, INDUSTRIAL PARK, HEKOU TOWN,YANSHAN COUNTY, JIANGXI PROVINCE, CHINA
Doi:10.1016/j.ejmech.2015.01.064
(2015)Doi:10.1016/0040-4039(96)00777-0
(1996)Doi:10.1021/om4010862
(2014)Doi:10.1021/jo01267a052
(1968)Doi:10.1039/c39930001226
(1993)Doi:10.1016/S0020-1693(00)83155-2
(1989)
