Asymmetric synthesis of the δ-lactone moiety in mevinic acid derivatives using an enzymatic procedure

Article abstract of DOI:10.1016/S0957-4166(96)00508-3

Asymmetric induction into meso-1,3-diacetoxy-5-cycloheptene 4 by PFL-catalyzed hydrolysis afforded monoacetate (1S,3R)-5 of 96% enantiomeric excess (e.e.), which was converted into a synthetic equivalent 14 of the δ-lactone moiety in mevinic acid derivatives.