Pyrrolidinopiperazinedione as chiral auxillary and its use in asymmetric Mannich synthesis

Article abstract of DOI:10.1016/S0040-4039(97)00130-5

Functionalised diketopiperazines (DKPs) are easily obtained optically pure by disymmetrization of a mesopyrrolidine and can be easily converted to an α-amino amine containing compound. As a first example, one of the new chiral auxiliaries has been used to prepare an optically pure β-amino ester through a Mannich reaction.