An efficient stereoselective synthesis of 1α,24(R)-dihydroxyvitamin D3 by the dienyne route

DOI: 10.1016/S0040-4020(97)00139-7

Source and publish data:

Tetrahedron p. 4703 - 4714 (1997)

Update date:2022-08-03

Topics:

Authors:

Fall, Yagamare

Torneiro, Mercedes

Castedo, Luis

Mourino, Antonio

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Article abstract of DOI:10.1016/S0040-4020(97)00139-7

1α,24(R)-Dihydroxyvitamin D₃ (5e) was synthesized. The key step in the preparation of the side-chain was opening of the chiral epoxide 10 by the α-anion of the nitrile 9. The triene system was synthesized by the dienyne route.

Full text of DOI:10.1016/S0040-4020(97)00139-7

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Product name:(24R)-1α-[(tert-butyldimethylsilyl)oxy]-6,7-didehydro-24-[(methoxymethyl)oxy]-previtamin D₃ tert-butyldimethylsilyl ether

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