Beta-amino acid derivatives as orally active non-peptide fibrinogen receptor antagonists

Article abstract of DOI:10.1016/S0960-894X(97)00095-4

The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of the platelet fibrinogen receptor GPIIb/IIIa.