Bioorganic and Medicinal Chemistry Letters p. 727 - 732 (1997)
Update date:2022-08-03
Topics:
Kottirsch, Georg
Zerwes, Hans-Guenther
Cook, Nigel S.
Tapparelli, Carlo
The ornithine sulfonamide 1 was identified by random screening as weak fibrinogen receptor antagonist. Homologation of the carboxylic acid function and further structure activity studies led to the development of novel beta-amino acid derivatives, which are potent and orally active antagonists of the platelet fibrinogen receptor GPIIb/IIIa.
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(1997)Doi:10.1016/S0040-4039(97)00397-3
(1997)Doi:10.1271/bbb.61.743
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(1997)Doi:10.1016/S0022-328X(96)06486-8
(1997)Doi:10.1016/S0008-6215(97)00022-0
(1997)
