Name: L-Leucine
SKU: 61-90-5

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Basic Information

Molecular Structure:
CAS No.:	61-90-5
Name:	L-Leucine

Formula:	C₆H₁₃NO₂
Molecular Weight:	131.175
Synonyms:	L(+)-Leucine;.alpha.-Aminoisocaproic acid;2-Amino-4-methylpentanoic acid, (S)-;L-Norvaline, 4-methyl-;L-alpha-Aminoisocaproic acid;Leucine (USP);2-Amino-4-methylvaleric acid (L);(2S)-alpha-Leucine;Pentanoic acid, 2-amino-4-methyl-, (S)-;(S)-2-Amino-4-methyl-pentanoic acid;Leucine, L-;2-Amino-4-methylpentanoic acid;(S)-(+)-leucine;Pentanoic acid, 2-amino-4-methyl-;Leu;Valeric acid, 2-amino-4-methyl-, (S)-;(2S)-2-azaniumyl-4-methyl-pentanoate;(S)-2-Amino-4-methylvaleric acid;(2S)-2-amino-4-methylpentanoic acid;Norvaline, 4-methyl-;L-Leuzin;L-2-Amino-4-methylpentanoic acid;(2S)-alpha-2-Amino-4-methylvaleric acid;FEMA No. 3297;2-Amino-4-methylpentanoic acid (L);(S)-leucine;
EINECS:	200-522-0
Density:	1.036 g/cm³
Melting Point:	>300 °C(lit.)
Boiling Point:	225.8 °C at 760 mmHg
Flash Point:	90.3 °C
Solubility:	22.4 g/L (20 °C) in water
Appearance:	White crystalline powder
Safety:	24/25
PSA:	63.32000
LogP:	1.14470

Synthetic route

: 439912-47-7
Poc-Leu-OH

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With resin bound tetrathiomolybdate In methanol at 28℃; for 1.5h; ultrasonic bath;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With water at 170℃; for 0.05h; Microwave irradiation;	100%
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	98%
Multi-step reaction with 3 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: trifluoroacetic acid 3: E. coli BL21 Star (DE3) S30 extract / aq. buffer / 6 h / 37 °C / pH 7.5 View Scheme
Multi-step reaction with 3 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: trifluoroacetic acid 3: E. coli BL21 Star (DE3) S30 extract / aq. buffer / 6 h / 37 °C / pH 7.5 View Scheme
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h;

: N-(L-leucyl)-β-D-glucopyranosylamine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With pronase In water at 37℃; for 46h; Time; Enzymatic reaction;	100%

: 2899-43-6
DL-leucine ethyl ester

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With 3,5-dinitrosalicylaldehyde; Alcalase In water; acetonitrile at 35℃; for 3h; pH=7.5; Enzymatic reaction; optical yield given as %ee;	99%

: (3S,5S)-3-Isobutyl-5-phenyl-morpholin-2-one

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogen; trifluoroacetic acid; palladium dihydroxide In methanol; water under 3750.3 Torr; for 24h;	98%

: 111-26-2
hexan-1-amine

: 78641-71-1
(S)-2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-4-methyl-pentanoic acid

A: 61-90-5
L-leucine

B: 74197-48-1
1-hexyl-3,5-dinitro-4-pyridone

Conditions

Conditions	Yield
In pyridine Product distribution;	A 97% B n/a

...Expand

: 108437-94-1
(2S,5S)-N-<(S)-N-bis(methylthio)methyleneleucyl>-2,5-bis(methoxymethoxymethyl)pyrrolidine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogenchloride for 4h; Heating;	96%

: 328-39-2
LEUCINE

: 61-90-5
L-leucine

Conditions

Conditions	Yield
In water at 37℃; for 2h; NADH, ammonium chloride, sodium formate, D-amino acid oxidase, catalase, leucine dehydrogenase, formate dehydrogenase, Tris-HCl buffer, pH 8.5;	95%
With porcine kidney D-amino acid oxidase (EC 1.4.3.3.); sodium cyanoborohydride; flavin adenine dinucleotide In phosphate buffer at 37℃;	90%
With D-amino acid oxidase; E. coli branched-chain amino acid aminotransferase In water at 37℃; for 72h; Tris buffer, pH 8.5, 1mM EDTA, monosodium glutamate, bovine serum albumin, catalase, pyridoxal 5'-phosphate;	87%

: 98204-51-4
(S)-2-[{(allyloxy)carbonyl}amino]-4-methylpentanoic acid

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; bis-triphenylphosphine-palladium(II) chloride In dichloromethane Ambient temperature;	95%

: 26117-20-4
N-carbamoyl-L-leucine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With NH4Cl-NH4OH buffer pH 8.5; nickel dichloride at 60℃; for 24h; N-carbamyl-L-amino acid aminohydrolase;	94%
With Tris-HCl buffer; N-carbamoyl-L-amino acid hydrolase; iron(II) sulfate at 30℃; for 2h;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 1h;

Raw Materials

Downstream Products

124-38-9

100-02-7

7664-41-7

2018-66-8

123-51-3

64-18-6

13139-15-6

35661-60-0

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

1. Introduction of L-Leucine

L-Leucine, with the IUPAC Nameof (2S)-2-amino-4-methylpentanoic acid, is one kind of white crystalline powder. For being stable in the normal condition, it si sensitive to moisture and light, and this chemical is incompatible with strong oxidising agents. Besides, it belongs to the Product Categories which include Food and Feed Additive; Amino Acid Derivatives; Leucine [Leu, L]; Amino Acids; Amino Acids and Derivatives; alpha-Amino Acids; Biochemistry; Nutritional Supplements; L-Amino Acids; Amino Acids.

2. Properties of L-Leucine

L-Leucine has the following property datas: (1)Index of Refraction: 1.462; (2)Molar Refractivity: 34.86 cm³; (3)Molar Volume: 126.6 cm³; (4)Polarizability: 13.82×10-24cm³; (5)Surface Tension: 39 dyne/cm; (6)Density: 1.035 g/cm³; (7)Flash Point: 90.3 °C; (8)Enthalpy of Vaporization: 50.93 kJ/mol; (9)Melting Point: >300 °C(lit.); (10)Boiling Point: 225.8 °C at 760 mmHg; (11)Vapour Pressure: 0.0309 mmHg at 25°C; (12)Solubility: 1 M HCl: 50 mg/mL; (13)Water Solubility: 22.4 g/L (20 C).

3. Structure Descriptors of L-Leucine

You could convert the following datas into the molecular structure:
(1). InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
(2). InChIKey: InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N
(3). Smiles: C([C@@H](C(O)=O)N)C(C)C

4. Toxicity of L-Leucine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LDLo	subcutaneous	2620mg/kg (2620mg/kg)		Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 40, Pg. 313, 1898.
rat	LD50	intraperitoneal	5379mg/kg (5379mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.

5. Safety Information of L-Leucine

Safety Statements of L-Leucine (CAS NO.61-90-5): 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: OH2850000
HS Code: 29224995
Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

6. Use and Preparation of L-Leucine

L-Leucine is used for pharmaceutical raw materials and food additives. As a food additive, it has E number E641 and is classified as a flavour enhancer.

61-90-5

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Consensus Reports

Specification